Love, Marriage, Infertility, Miscarriage, Twins, near 2nd tri losses... It's been quite a ride...
Our first two years together (05-06):
2005:
1/2: Met on blind date (after e-mailing and too busy to meet since Nov. '04)
Nov.: Moved into S's suburban townhouse (gave up lakeside apt. in Lincoln Park, traded Vespa for Volvo, then celebrated S's 30th @ the Bellagio in Vegas)
12/28: Sold DH's townhouse and closed on our first home together in the burbs
2006:
1/2: Officially engaged (on 1st anni of 1st date)
9/16: Married in U.S. (long weekend honeymoon #1 @ The Abbey on Lake Geneva)
9/24: Me = 30!
11/10-11/12 Wedding in India (honeymoon #2 before and after in London and Rajasthan, India)
Dec. Stop taking BCP (after ~10 years, after sister E nearly dies from PE - believed to be brought on by BCP)
Our next two years - 07-08 (original plan was one, it's a long story...):
Focused on enjoying being married, traveling, finally getting Lasik, renovating our home, climbing the corporate ladder, S's professional certification (and associated classes), small business, and permanent residency, etc.
TTC History (the last two plus years...):
In short, five RE's (so far), three surgeries (including lap/scope combo), three failed IUIs (2 w/CC, 1 w/Follistim/P4/acu), one IVF = singleton pregnancy and spontaneous miscarriage in 9th week, one FET = pg #2. (also acupuncture, yoga, and herbs)
2008:
Last summer b4 baby: take tennis and sailing lessons (again...)
8/08: Preconception appt. for us both w/gyne @ annual visit (CF testing, etc. - cleared to go), boss's DH succumbs after five yr. battle w/brain cancer and she returns to relieve me at work.
10/08 Started TTC (I'm super regular, this should be easy, right? ;) )
11/08 Tried OPK
12/08 Started using CBEFM (bottom falls out at work, project cancelled, VPs fired)
2009:
1/09 Tested fertility at home w/Fertell test (FSH/OR and motility all normal)
4/09 First trip to RE (SA-"normal" = wrong!, me-uterine polyp & septum), turn down job in Boston, niece is dx w/craniosynostosis and has major surgery in July when sister announces third pregnancy in as many yrs.
5/09 Hysteroscopy to remove uterine polyp (outpatient, general), RE wouldn't touch septum (DH takes new job w/IF lifetime of $15K!)
6-9/09 Continued trying on our own
One year into TTC, we begin treatments...:
10/09 1st Clomid 50mg/Ovidrel/IUI cycle = BFN (AF on time (12dpO), no beta)
11/09 2nd Clomid 50mg/late IUI (RE waited for more follies, O'd on own) = BFN (AF on time, no beta)
12/09 Changed RE's, started yoga and acupuncture for fertility, new RE orders MRI, do more research on septums, join The Bump IF board
2010:
1/22: Begin blogging...
1/29 Hysteroscopy to resection uterine septum (outpatient, local)
3 wks post-op: Premarin/E2(5mg), add Provera/P4 3rd wk, then wait for AF.
2/23 CD1
3/10 trying on own for 1st time post-op = BFN, started herbs
4/6 rescheduled (from March) CD10 saline sonohysterogram = all clear! (not!)
4/23 7dpo Prog test = 7.48 (too low), start Crinone supps in LP=BFN
5/4 Consult w/RE, plan to do IUI w/CC/injects/acu CD3: start CC 100mg=severe abdominal pain, stop Clomid
5/5-10 Follistim 50IU
5/11-12 Follistim 100IU
5/13 Ovidrel trigger
5/15 IUI
5/17 begin Crinone
5/27 Beta = BFFN :(
5/28 rescheduled phone consult w/Dr. Sami David, also CD1...
June: Dr. David recos no treatment - doing more diagnostics, start extra Vitamin D
6/9 Start Quietude to help sleep through the night
6/10 Consult w/Dr. F (discuss lap vs. IVF and do cervical culture-CD14-group b beta strep culture)
6/18 new SA w/Dr. D in NYC (morph=1% :(, count and motility excellent), 3 bacteria cultures-pseudomonas), P4 on CD22 (18.9)
6/22 appt. w/Dr. Tu (endo surgeon), scheduling lap for ASAP
7/1 test positive for group b beta strep, start Erythromycin BS 250 (10 days, 4x/day). DH tests positive for pseudomonas
7/6 S begins 20 days of Cipro
7/8 S to urologist-exam fine, no surgery needed (thank goodness)
7/19 IVF consult w/Dr. Sherbahn @ Advanced Fertility, 3D u/s revealed remaining septum, stop Crinone to avoid possible pg (who am I kidding?)
7/26 septum resection consult w/ Dr. Deutch
8/4 septum resection (take two) and a laparoscopy (very minor endo found, everything looks fine)
8/5 begin post-op meds... 3wks of 2.5mg of Premarin/E2, 1wk of Doxycycline, last wk of E2 add P4/Provera.
8/6 uterine balloon removed (and none too soon...), reaction to surgery/balloon
w/o 8/15 dx w/HSV while on vacation, g-ma dx w/terminal cancer :(
8/25 last day of post-op meds
8/27 CD1 (and it's a doozy...)
8/31 annual w/gyne, blood test for HSV-2 (negative!), but + for HSV-1 (no big whoop)
9/2 follow up 3-D u/s to make sure all is clear, can't see, rescheduled
9/6 start OPK
9/8 mock transfer and follow-up 3D u/s (ready to go, finally!)
9/11 bilateral mammogram (more fun!, but cancer-free), IVF meds arrive
9/12 FIL passes away unexpectedly, IVF #1 on hold until we return from India in Oct. (sister dx w/cancer during routine surgery while we are gone, later has another surgery and is cleared)
10/1-2 CD1 (here we go! one fresh cycle on the man, please let this work!)
10/15 + OPK, call AF for schedule, DH gives sample for SA and frozen
10/20: SA #3 results in: count 80MM, motility 48%, morphology 4% (improved)
10/23 begin 10 units Lupron and baby aspirin nightly
11/4: CD1
11/5: baseline b/w and u/s
11/6: acu, Gonal F stims (225), HCG (4), baby aspirin (AM), 5 Lupron (PM)
11/7: AM: 112.5 Gonal F, 4 HCG, baby aspirin, PM: 75 Gonal F, 5 Lupron
11/8: AM: 112.5 Gonal F, 4 HCG, baby aspirin, PM: 75 Gonal F, 5 Lupron
11/9: follie check u/s and b/w, baby asp, PM: 188 G-F, 4 HCG, 5 Lupron
11/10: AM: 112 G-F, baby asp, PM: 75 G-F, 4 HCG, 5 Lup
11/11: follie check u/a and b/w, acu, baby asp, PM: 300 G-F, 4 HCG, 5 Lup
11/12: AM: 150 G-F, baby asp, PM: 112.5 G-F, 4 HCG, 5 Lup
11/13: AM: follie check u/s and b/w, PM: 300 G-F, 6 HCG, 5 Lup, BA
11/14: AM: follie check u/s and b/w, PM: 225 G-F, trigger @ 10:30pm
11/16: ER @ 8:30am, 10 eggs retrieved, ICSI, begin tetracycline and medrol
11/17: Fert report, of 10 retrieved, 7 mature, 5 fertilized, 5 embies growing, add baby aspirin and PIO
11/18: pre-ET acu (just in case), stop tetracycline
11/19: 3dt of 2 embies (1 8-cell and 1 6-cell), stop medrol
11/20: post ET acu
11/22: DH turns 35
11/23: start estrogen patches (3 new, every 3 days)
11/27: First ever + HPT!
11/29: Back to work
11/30: Beta #1 = 104!, transitioning off of PIO to Crinone (2x/day)
12/3: Beta #2 = 490!
12/5: wean off of E2 patches (down to 2 today, one on 12/8, then stop)
12/10: Beta #3 = 3764 (last day on E2, continue P4 and baby aspirin)
12/21: 1st u/s @ 7wks.= one perfect bean w/heartbeat, stop baby aspirin
12/22: DH leaves for India to take care of late father's affairs for 2 1/2 wks
12/29-30: spontaneous m/c @ 8w2d, (9 hrs post-m/c) hCG = 16,503 (baby: normal female, unknown cause of m/c)
2011:
Jan: Sister needs chemo after change in tumor grade, chemo through May
1/6: hCG (1 wk post) = 335
1/9: DH returns from India :)
1/13: hCG (2 wks post) = 51
1/20: hCG (3 wks post) = 11 / consult/WTF w/ Dr. S, ACA/LAC testing (normal)
1/31: hCG (4 1/2 wks post) = 3.9 :/
2/7: AF finally arrives, 5 1/2 wks. post m/c
2/15: hysteroscopy (in office, no sedation) - karyotyping (normal), TSH (normal) and APA testing (TBD)
2/17: Consult w/septum surgeon (add'l surgery not recoed, ute is fine, septum 7mm)
Mar-May 2011: FET
3/12: CD1-prep cycle
3/13-25: BCP, then bleed again
3/23-TBD: 10 units of Lupron and baby aspirin daily
4/1: b/w-u/s baseline appt. (lower dosage of Lupron to 5 units daily)
4/1: begin E2 patches, changing every 3 days (start w/1, then 2, then 4...)
4/2: acu
4/4: 2 patches
4/7: 4 patches
4/9: acu
4/10: 4 patches
4/13: 4 patches (last day of FT job)
4/14: acu
4/15: b/w-u/s-lining check appt.
4/16: 4 patches (grandfather passes away suddenly)
4/19: 4 patches
4/20: last day of Lupron 5 units (nearly miss funeral returning from OOT work trip)
4/21: P4 check
4/21: acu
4/21: begin PIO (1.5ml), Medrol (16mg @ bedtime) and tetracycline (4 x 250mg) daily, down to 2 patches
4/26: acu
4/27: scheduled 5dt
4/28: acu
5/1: + HPT!
5/5: acu
5/6: beta #1 - 197 (9dp5dt) (EDD 1/12/12, or 12/21/11 for two)
5/9: beta #2 - 480 (12dp5dt) (doubling time of 56 hrs.)
5/16: beta #3 - 7078! (19dp5dt)
5/24: 1st u/s @ 6w4d, TWINS!!
6/1: 2nd u/s/last w/RE @ 7w5d
6/6: 1st u/s w/OB @ 8w3d
6/10: 1st consult w/OB @9w (then rush to WI as g-ma is hospitalized, she passes away on 6/11 :( )
6/21: b/w w/reproductive geneticist
6/28: 12wk OB appt. & u/s (@11w4d)
Second Trimester:
7/5: b/w results and u/s w/repro geneticist (perfect!), apply last E2 patch!!!
7/8: Remove last E2 patch!, start weaning off of PIO (down to 1cc tonight for one wk, then one wk @ .5cc), 13 weeks!
7/22: Last PIO shot!!! (15w)
7/26: 15w4d u/s: Looks like we are expecting a boy and a girl!!
7/31: 3D gender scan
8/19: 19w: Lose mucus plug, OB finds HBs and cervix is long and closed
8/25: Quad screen results: normal, anatomy scan @ 19w6d: babies look great, but cervix funneling and only 2.5cm=bedrest
8/26: 20w: first trip to maternity triage for pain, babies are fine, not contracting
8/29: 20w4d: MFM appt.: cervix is stable, start Crinone and twice weekly cervical checks
9/1: 21w: cervix up to 3.75cm and closed after week of bed rest and 3 days of P4, continue treatment
9/6: 21w5d: cervical regression and opening, emergent cerclage at 2cm dilation to prevent loss, begin weekly P17 shots/cervix checks, on total bed rest until babies arrive
12/16: Cerclage removed @ 36weeks
12/20: Babies are born @ 36w4d via emergency Ceasarean!!
2012:
Me: Pumping exclusively-12 months, Shingles @ 4 months, Carpal tunnel first six months
dx: a bunch of red herrings... "mild ovulatory dysfunction" (lowish E2 & low P4, though I'm super regular I consistently O ~CD 17 and have a 12d LP), very minor endo, a nearly complete uterine septum that has been resected/"removed" twice. DH: low morph 1-4% on 2nd/3rd SA (teratozoospermia), borderline/low motility on 1st/3rd SA (35-48%) (Asthenozoospermia), or as my latest RE calls us "unexplained" ???
What I take: Nature Made PNV w/DHA (back to Rainbow Light for IVF and pg), Omega 3-Fish Oil (1200mg), Cranberry extract (300mg)-for UTI prevention, Vit D (1000IU), sometimes baby aspirin (81mg), P4 supps (Crinone) in LP/2WW. DH on ConceptionXR for IVF.
Our first two years together (05-06):
2005:
1/2: Met on blind date (after e-mailing and too busy to meet since Nov. '04)
Nov.: Moved into S's suburban townhouse (gave up lakeside apt. in Lincoln Park, traded Vespa for Volvo, then celebrated S's 30th @ the Bellagio in Vegas)
12/28: Sold DH's townhouse and closed on our first home together in the burbs
2006:
1/2: Officially engaged (on 1st anni of 1st date)
9/16: Married in U.S. (long weekend honeymoon #1 @ The Abbey on Lake Geneva)
9/24: Me = 30!
11/10-11/12 Wedding in India (honeymoon #2 before and after in London and Rajasthan, India)
Dec. Stop taking BCP (after ~10 years, after sister E nearly dies from PE - believed to be brought on by BCP)
Our next two years - 07-08 (original plan was one, it's a long story...):
Focused on enjoying being married, traveling, finally getting Lasik, renovating our home, climbing the corporate ladder, S's professional certification (and associated classes), small business, and permanent residency, etc.
TTC History (the last two plus years...):
In short, five RE's (so far), three surgeries (including lap/scope combo), three failed IUIs (2 w/CC, 1 w/Follistim/P4/acu), one IVF = singleton pregnancy and spontaneous miscarriage in 9th week, one FET = pg #2. (also acupuncture, yoga, and herbs)
2008:
Last summer b4 baby: take tennis and sailing lessons (again...)
8/08: Preconception appt. for us both w/gyne @ annual visit (CF testing, etc. - cleared to go), boss's DH succumbs after five yr. battle w/brain cancer and she returns to relieve me at work.
10/08 Started TTC (I'm super regular, this should be easy, right? ;) )
11/08 Tried OPK
12/08 Started using CBEFM (bottom falls out at work, project cancelled, VPs fired)
2009:
1/09 Tested fertility at home w/Fertell test (FSH/OR and motility all normal)
4/09 First trip to RE (SA-"normal" = wrong!, me-uterine polyp & septum), turn down job in Boston, niece is dx w/craniosynostosis and has major surgery in July when sister announces third pregnancy in as many yrs.
5/09 Hysteroscopy to remove uterine polyp (outpatient, general), RE wouldn't touch septum (DH takes new job w/IF lifetime of $15K!)
6-9/09 Continued trying on our own
One year into TTC, we begin treatments...:
10/09 1st Clomid 50mg/Ovidrel/IUI cycle = BFN (AF on time (12dpO), no beta)
11/09 2nd Clomid 50mg/late IUI (RE waited for more follies, O'd on own) = BFN (AF on time, no beta)
12/09 Changed RE's, started yoga and acupuncture for fertility, new RE orders MRI, do more research on septums, join The Bump IF board
2010:
1/22: Begin blogging...
1/29 Hysteroscopy to resection uterine septum (outpatient, local)
3 wks post-op: Premarin/E2(5mg), add Provera/P4 3rd wk, then wait for AF.
2/23 CD1
3/10 trying on own for 1st time post-op = BFN, started herbs
4/6 rescheduled (from March) CD10 saline sonohysterogram = all clear! (not!)
4/23 7dpo Prog test = 7.48 (too low), start Crinone supps in LP=BFN
5/4 Consult w/RE, plan to do IUI w/CC/injects/acu CD3: start CC 100mg=severe abdominal pain, stop Clomid
5/5-10 Follistim 50IU
5/11-12 Follistim 100IU
5/13 Ovidrel trigger
5/15 IUI
5/17 begin Crinone
5/27 Beta = BFFN :(
5/28 rescheduled phone consult w/Dr. Sami David, also CD1...
June: Dr. David recos no treatment - doing more diagnostics, start extra Vitamin D
6/9 Start Quietude to help sleep through the night
6/10 Consult w/Dr. F (discuss lap vs. IVF and do cervical culture-CD14-group b beta strep culture)
6/18 new SA w/Dr. D in NYC (morph=1% :(, count and motility excellent), 3 bacteria cultures-pseudomonas), P4 on CD22 (18.9)
6/22 appt. w/Dr. Tu (endo surgeon), scheduling lap for ASAP
7/1 test positive for group b beta strep, start Erythromycin BS 250 (10 days, 4x/day). DH tests positive for pseudomonas
7/6 S begins 20 days of Cipro
7/8 S to urologist-exam fine, no surgery needed (thank goodness)
7/19 IVF consult w/Dr. Sherbahn @ Advanced Fertility, 3D u/s revealed remaining septum, stop Crinone to avoid possible pg (who am I kidding?)
7/26 septum resection consult w/ Dr. Deutch
8/4 septum resection (take two) and a laparoscopy (very minor endo found, everything looks fine)
8/5 begin post-op meds... 3wks of 2.5mg of Premarin/E2, 1wk of Doxycycline, last wk of E2 add P4/Provera.
8/6 uterine balloon removed (and none too soon...), reaction to surgery/balloon
w/o 8/15 dx w/HSV while on vacation, g-ma dx w/terminal cancer :(
8/25 last day of post-op meds
8/27 CD1 (and it's a doozy...)
8/31 annual w/gyne, blood test for HSV-2 (negative!), but + for HSV-1 (no big whoop)
9/2 follow up 3-D u/s to make sure all is clear, can't see, rescheduled
9/6 start OPK
9/8 mock transfer and follow-up 3D u/s (ready to go, finally!)
9/11 bilateral mammogram (more fun!, but cancer-free), IVF meds arrive
9/12 FIL passes away unexpectedly, IVF #1 on hold until we return from India in Oct. (sister dx w/cancer during routine surgery while we are gone, later has another surgery and is cleared)
10/1-2 CD1 (here we go! one fresh cycle on the man, please let this work!)
10/15 + OPK, call AF for schedule, DH gives sample for SA and frozen
10/20: SA #3 results in: count 80MM, motility 48%, morphology 4% (improved)
10/23 begin 10 units Lupron and baby aspirin nightly
11/4: CD1
11/5: baseline b/w and u/s
11/6: acu, Gonal F stims (225), HCG (4), baby aspirin (AM), 5 Lupron (PM)
11/7: AM: 112.5 Gonal F, 4 HCG, baby aspirin, PM: 75 Gonal F, 5 Lupron
11/8: AM: 112.5 Gonal F, 4 HCG, baby aspirin, PM: 75 Gonal F, 5 Lupron
11/9: follie check u/s and b/w, baby asp, PM: 188 G-F, 4 HCG, 5 Lupron
11/10: AM: 112 G-F, baby asp, PM: 75 G-F, 4 HCG, 5 Lup
11/11: follie check u/a and b/w, acu, baby asp, PM: 300 G-F, 4 HCG, 5 Lup
11/12: AM: 150 G-F, baby asp, PM: 112.5 G-F, 4 HCG, 5 Lup
11/13: AM: follie check u/s and b/w, PM: 300 G-F, 6 HCG, 5 Lup, BA
11/14: AM: follie check u/s and b/w, PM: 225 G-F, trigger @ 10:30pm
11/16: ER @ 8:30am, 10 eggs retrieved, ICSI, begin tetracycline and medrol
11/17: Fert report, of 10 retrieved, 7 mature, 5 fertilized, 5 embies growing, add baby aspirin and PIO
11/18: pre-ET acu (just in case), stop tetracycline
11/19: 3dt of 2 embies (1 8-cell and 1 6-cell), stop medrol
11/20: post ET acu
11/22: DH turns 35
11/23: start estrogen patches (3 new, every 3 days)
11/27: First ever + HPT!
11/29: Back to work
11/30: Beta #1 = 104!, transitioning off of PIO to Crinone (2x/day)
12/3: Beta #2 = 490!
12/5: wean off of E2 patches (down to 2 today, one on 12/8, then stop)
12/10: Beta #3 = 3764 (last day on E2, continue P4 and baby aspirin)
12/21: 1st u/s @ 7wks.= one perfect bean w/heartbeat, stop baby aspirin
12/22: DH leaves for India to take care of late father's affairs for 2 1/2 wks
12/29-30: spontaneous m/c @ 8w2d, (9 hrs post-m/c) hCG = 16,503 (baby: normal female, unknown cause of m/c)
2011:
Jan: Sister needs chemo after change in tumor grade, chemo through May
1/6: hCG (1 wk post) = 335
1/9: DH returns from India :)
1/13: hCG (2 wks post) = 51
1/20: hCG (3 wks post) = 11 / consult/WTF w/ Dr. S, ACA/LAC testing (normal)
1/31: hCG (4 1/2 wks post) = 3.9 :/
2/7: AF finally arrives, 5 1/2 wks. post m/c
2/15: hysteroscopy (in office, no sedation) - karyotyping (normal), TSH (normal) and APA testing (TBD)
2/17: Consult w/septum surgeon (add'l surgery not recoed, ute is fine, septum 7mm)
Mar-May 2011: FET
3/12: CD1-prep cycle
3/13-25: BCP, then bleed again
3/23-TBD: 10 units of Lupron and baby aspirin daily
4/1: b/w-u/s baseline appt. (lower dosage of Lupron to 5 units daily)
4/1: begin E2 patches, changing every 3 days (start w/1, then 2, then 4...)
4/2: acu
4/4: 2 patches
4/7: 4 patches
4/9: acu
4/10: 4 patches
4/13: 4 patches (last day of FT job)
4/14: acu
4/15: b/w-u/s-lining check appt.
4/16: 4 patches (grandfather passes away suddenly)
4/19: 4 patches
4/20: last day of Lupron 5 units (nearly miss funeral returning from OOT work trip)
4/21: P4 check
4/21: acu
4/21: begin PIO (1.5ml), Medrol (16mg @ bedtime) and tetracycline (4 x 250mg) daily, down to 2 patches
4/26: acu
4/27: scheduled 5dt
4/28: acu
5/1: + HPT!
5/5: acu
5/6: beta #1 - 197 (9dp5dt) (EDD 1/12/12, or 12/21/11 for two)
5/9: beta #2 - 480 (12dp5dt) (doubling time of 56 hrs.)
5/16: beta #3 - 7078! (19dp5dt)
5/24: 1st u/s @ 6w4d, TWINS!!
6/1: 2nd u/s/last w/RE @ 7w5d
6/6: 1st u/s w/OB @ 8w3d
6/10: 1st consult w/OB @9w (then rush to WI as g-ma is hospitalized, she passes away on 6/11 :( )
6/21: b/w w/reproductive geneticist
6/28: 12wk OB appt. & u/s (@11w4d)
Second Trimester:
7/5: b/w results and u/s w/repro geneticist (perfect!), apply last E2 patch!!!
7/8: Remove last E2 patch!, start weaning off of PIO (down to 1cc tonight for one wk, then one wk @ .5cc), 13 weeks!
7/22: Last PIO shot!!! (15w)
7/26: 15w4d u/s: Looks like we are expecting a boy and a girl!!
7/31: 3D gender scan
8/19: 19w: Lose mucus plug, OB finds HBs and cervix is long and closed
8/25: Quad screen results: normal, anatomy scan @ 19w6d: babies look great, but cervix funneling and only 2.5cm=bedrest
8/26: 20w: first trip to maternity triage for pain, babies are fine, not contracting
8/29: 20w4d: MFM appt.: cervix is stable, start Crinone and twice weekly cervical checks
9/1: 21w: cervix up to 3.75cm and closed after week of bed rest and 3 days of P4, continue treatment
9/6: 21w5d: cervical regression and opening, emergent cerclage at 2cm dilation to prevent loss, begin weekly P17 shots/cervix checks, on total bed rest until babies arrive
12/16: Cerclage removed @ 36weeks
12/20: Babies are born @ 36w4d via emergency Ceasarean!!
2012:
Me: Pumping exclusively-12 months, Shingles @ 4 months, Carpal tunnel first six months
dx: a bunch of red herrings... "mild ovulatory dysfunction" (lowish E2 & low P4, though I'm super regular I consistently O ~CD 17 and have a 12d LP), very minor endo, a nearly complete uterine septum that has been resected/"removed" twice. DH: low morph 1-4% on 2nd/3rd SA (teratozoospermia), borderline/low motility on 1st/3rd SA (35-48%) (Asthenozoospermia), or as my latest RE calls us "unexplained" ???
What I take: Nature Made PNV w/DHA (back to Rainbow Light for IVF and pg), Omega 3-Fish Oil (1200mg), Cranberry extract (300mg)-for UTI prevention, Vit D (1000IU), sometimes baby aspirin (81mg), P4 supps (Crinone) in LP/2WW. DH on ConceptionXR for IVF.